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Multiethnic Genome-Wide Meta-Analysis of Ectopic Fat Deposits

Gastric band Surgery In France Multiethnic Genome-Wide Meta-Analysis of Ectopic Fat Depots Identifies Loci Associated With Adipocyte Development and Differentiation. Figure 1 Functional characterization of Atxn1, Ebf1, Rreb1 and Ube2e2 (a,b,e) Data is displayed as box/whisker plots where the center line represents the median, box limits contain the 25th-75th percentiles, and whiskers span max/min values. (a) Gene expression measured by qPCR in murine subcutaneous (SAT), perigonadal visceral (VAT), and pericardial (PAT) adipose tissues (n=6 mice). Statistical significance was assessed using ANOVA and Sidak's correction for multiple comparisons. (b) Gene expression measured by qPCR in murine adipose tissues after 8 weeks of high fat feeding compared to normal chow fed controls (n=5 mice per group). Statistical significance was assigned using a two-sided T-test. (c) Gene expression measured by qPCR in cultured adipocyte progenitors isolated from the subcutaneous (SAT) or perigonadal visceral (VAT) depots (n=4 replicates). Cells were expanded to confluence and then collected at intervals after induction of adipogenic differentiation. Data displayed as mean, error bar=s.e.m. Statistical significance was assessed using ANOVA and Sidak's correction for multiple comparisons to time 0. (d) Oil-red-o staining of progenitors isolated from subcutaneous adipose and exposed to retroviral delivery of shRNA constructs during ex vivo expansion and induction of adipogenesis. Relative to control vector carrying a scramble sequence, shRNA constructs specific for Atxn1 and Ube2e2 impaired adipogenic differentiation. Scale=1mm. (e) Oil-red-o stain was alcohol extracted and quantified at OD520 (n=9 technical replicates). Statistical significance was assessed using ANOVA and Sidak's correction for multiple comparisons to control (Scramble). Data representative of 3 independent experiments. For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more......>click Here< adjustable gastric band surgery is a stomach bands for weight loss and gastric surgery Read more... Read more...

How to control your appetite naturally

Gastric band Surgery In France Hunger is an important, natural reminder for people to keep their bodies fueled. But often, an appetite can come back even when we have eaten enough. High appetites can be caused by the kinds of food we eat, the way we eat them, and diet plans that leave a person feeling hungry, among other reasons. Weight loss pills make big claims about suppressing appetite but their effectiveness is uncertain, and they often come with dangerous side effects. The following techniques are natural, risk-free methods to suppress appetite. They can be put into action to tackle hunger cravings in a healthful way. Natural ways to suppress appetite There is a range of things a person can due to reduce their appetite, including: 1. Eating more protein or fat high protein food Eating foods rich in protein or fat may help reduce hunger cravings. Not all foods satisfy hunger equally. Protein and fats are better than carbohydrates at reducing hunger, especially those high in sugar. Studies consistently show that protein and fats are essential for satisfying hunger and keeping people full for longer. Protein-rich foods recommended by the Dietary Guidelines for Americans include: lean meats eggs beans and peas nuts soy products Greek yogurt Foods that are good sources of fats include: nuts seeds avocado olive oil cheese coconut grass-fed butter eggs 2. Choosing high-fiber foods Fiber does not break down like other foods, so it stays in the body for longer. This slows down digestion and keeps people feeling full throughout the day. Research suggests that fiber can be an effective appetite suppressant. High-fiber diets are also associated with lower obesity rates. On the other hand, another review found that introducing extra fiber into the diet was effective in less than half of the studies they looked at. More research is needed to identify which sources of fiber are the most effective for suppressing appetite. High-fiber foods include: whole grains beans and pulses fruits, including apples and avocados almonds chia seeds vegetables 3. Drinking more fluids Drinking a large glass of water directly before eating has been found to make a person feel fuller, more satisfied, and less hungry after the meal. Another study, which looked at appetite in 50 overweight females, showed that drinking 1.5 liters of water a day for 8 weeks caused a reduction in appetite and weight, and also led to greater fat loss. A soup starter may also quench the appetite. Research from 2007 showed that people reported feeling fuller immediately after the meal if they had a liquid starter. 4. Eating large volumes of the right foods Reducing general food intake while dieting can leave people with a ravenous appetite. This can cause a relapse into binge eating. Dieting does not have to mean going hungry. Some foods are high in nutrients and energy, but low in calories. These include vegetables, fruits, beans, and whole grains. Eating a large volume of these foods will

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How to lose water weight naturally

Gastric band Surgery In France How to lose weight naturally by losing water weight Water weight, also called edema, is very common and rarely a cause for concern. However, it may feel uncomfortable and can cause unwanted bloating or puffiness in the body. This article outlines simple, healthy lifestyle tips for tackling water weight. Fast facts on water weight: Water normally makes up 50 to 60 percent of an adult's total body weight. Any extra water being held in the body is referred to as "water weight." When water builds up in the body, it can cause bloating and puffiness, especially in the abdomen, legs, and arms. Water levels can make a person's weight fluctuate by as much as 2 to 4 pounds in a single day. Severe water retention can be a symptom of heart or kidney disease. More often, it is temporary and goes away on its own or with some simple lifestyle changes. Ways to lose water weight There are a variety of ways a person can lose water weight quickly and naturally. We look at the most effective techniques: 1. Reduce sodium (salt) intake bottle of water with measuring tape Water weight may feel uncomfortable and cause bloating or puffiness in the body. An easy first step for beating water weight is to replace sodium-rich foods with low-sodium equivalents. Too much sodium, or salt, can cause immediate water retention. This is because the body needs to keep its sodium-to-water ratio balanced to function properly, so will hold on to water if too much salt is consumed. The latest Dietary Guidelines for Americans recommend no more than 2,300 milligrams (mg) of sodium per day. An average American will eat over 3,400 mg every day. Table salt is very high in sodium, but 75 percent of the sodium people consume is hidden in processed foods. These include cheese, cold meats, bread, frozen meals, soup mixes, and savory snacks. Natural foods, such as vegetables, nuts, and seeds, are very low in sodium. Some foods can even reduce sodium levels, including bananas, avocados, and leafy vegetables. 2. Drink more water While counterintuitive, drinking water can actually reduce water weight. Dehydration can make the body hold on to extra water to make up for lack of incoming water. Water also improves kidney function, allowing excess water and sodium to be flushed out of the system. Adults should drink around 2 liters of water a day. Replacing sugary drinks with pure water is a great way to keep up with the body's daily water needs. 3. Reduce carbohydrate intake Carbohydrates, or carbs, also cause the body to store extra water. When we eat carbs, the energy that we do not use right away is stored as glycogen molecules. Each gram (g) of glycogen comes with 3 g of water attached. Cutting down on carbs is a quick way to use up the glycogen stores, which means that the water weight will also be reduced. According to the Institute of Medicine's Food and Nutrition Board, adults need at least 130 g of carbohydrates to function each day, but the average American

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Sitting down can build fat around your organs, study shows

Gastric band Surgery In France The potential results of how Sitting down can build fat around your organs, according to a new study. Besides the ever-so-annoying belly fat, there's also a much more "invisible" - but just as harmful - kind of fat: one that sits around our internal organs. What causes this, and is it possible to get rid of it? A new study has some answers. Too much sitting down can build 'invisible' fat, says new study. For one thing, we need get off our tushies, and pronto! Sedentary time correlates directly with how much fat we build around our organs, according to the new study, which was published in the journal Obesity. For another, we need to exercise. The research shows that sitting has an even more harmful effect for those who don't work out enough. You might be tempted to think, "Thank you, Captain Obvious," but actually, few people are aware of the importance of body fat distribution and the fact that the fat around our organs puts us at serious risk of chronic illness. The new study was led by Dr. Joe Henson, research associate at the University of Leicester in the United Kingdom, who comments on the importance of the study, saying, "We know that spending long periods of time sedentary is unhealthy and a risk factor for chronic illnesses, such as type 2 diabetes and heart disease." "Likewise, the amount of fat deposited around our internal organs may also predispose us to these diseases," Dr. Henson says, and he's not the only one. In a previous study we reported on, visceral fat inside the abdominal cavity was shown to raise the risk of heart disease. For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more......>click Here< Read more... Read more...

The 10 best fitness blogs

Gastric band Surgery In France The 10 best fitness blogs Sign in Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences. Sign in Register for a free account For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more......>click Here< Read more... Read more...

Weight loss breakthrough: Sunlight is key

Gastric band Surgery In France Weight loss breakthrough: Sunlight is key Sign in Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences. Sign in Register for a free account For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more......>click Here< Read more... Read more...

Adipose-Derived Circulating miRNAs Regulate Gene Expression in Other Tissues.

1. Krol, J., Loedige, I. & Filipowicz, W. The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 11, 597-610 (2010) 2. Sun, L. et al. Mir193b-365 is essential for brown fat differentiation. Nat. Cell Biol. 13, 958-965 (2011) 3. Trajkovski, M. et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 474, 649-653 (2011) 4. Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009) 5. Ameres, S. L. & Zamore, P. D. Diversifying microRNA sequence and function. Nat. Rev. Mol. Cell Biol. 14, 475-488 (2013) 6. Arroyo, J. D. et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc. Natl Acad. Sci. USA 108, 5003-5008 (2011) 7. Thery, C., Amigorena, S., Raposo, G. & Clayton, A. Curr Protoc Cell Biol Chapter 3, Unit 3 22 (2006) 8. György, B. et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell. Mol. Life Sci. 68, 2667-2688 (2011) 9. Hata, A. & Lieberman, J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci. Signal. 8, re3 (2015) 10. Dumortier, O., Hinault, C. & Van Obberghen, E. MicroRNAs and metabolism crosstalk in energy homeostasis. Cell Metab. 18, 312-324 (2013) 11. Arner, E. et al. Adipose tissue microRNAs as regulators of CCL2 production in human obesity. Diabetes 61, 1986-1993 (2012) 12. Capobianco, V. et al. miRNA and protein expression profiles of visceral adipose tissue reveal miR-141/YWHAG and miR-520e/RAB11A as two potential miRNA/protein target pairs associated with severe obesity. J. Proteome Res. 11, 3358-3369 (2012) 13. Caroli, A., Cardillo, M. T., Galea, R. & Biasucci, L. M. Potential therapeutic role of microRNAs in ischemic heart disease. J. Cardiol. 61, 315-320 (2013) 14. Guay, C., Roggli, E., Nesca, V., Jacovetti, C. & Regazzi, R. Diabetes mellitus, a microRNA-related disease? Transl. Res. 157, 253-264 (2011) 15. Mori, M. A. et al. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 16, 336-347 (2012) 16. Mori, M. A. et al. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J. Clin. Invest. 124, 3339-3351 (2014) 17. Skog, J. et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 10, 1470-1476 (2008) 18. Taylor, D. D., Zacharias, W. & Gercel-Taylor, C. Exosome isolation for proteomic analyses and RNA profiling. Methods Mol. Biol. 728, 235-246 (2011) 19. Escola, J. M. et al. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 273, 20121-20127 (1998) 20. Février, B. & Raposo, G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 16, 415-421 (2004) 21. Ortega, F. J. et al. MiRNA expression profile of human

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The sleep diet: Could this work?

Gastric band Surgery In France The sleep diet: Could this work? Sign in Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences. Sign in Register for a free account For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more......>click Here< Read more... Read more...

Selective Antagonism of Muscarinic Receptors Is Neuroprotective in Peripheral Neuropathy.

Research ArticleNeuroscience Free access | 10.1172/JCI88321 Nigel A. Calcutt,1 Darrell R. Smith,2 Katie Frizzi,1 Mohammad Golam Sabbir,2 Subir K. Roy Chowdhury,2 Teresa Mixcoatl-Zecuatl,1 Ali Saleh,2 Nabeel Muttalib,1 Randy Van der Ploeg,2 Joseline Ochoa,1 Allison Gopaul,1 Lori Tessler,2 Jürgen Wess,3 Corinne G. Jolivalt,1 and Paul Fernyhough2,4 1Department of Pathology, UCSD, La Jolla, California, USA. 2Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada. 3Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA. 4Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Address correspondence to: Paul Fernyhough, R4046 - 351 Taché Avenue, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, R2H 2A6, Canada. Phone: 204.235.3692; E-mail: pfernyhough@sbrc.ca. Find articles by Calcutt, N. in: JCI | PubMed | Google Scholar 1Department of Pathology, UCSD, La Jolla, California, USA. 2Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada. 3Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA. 4Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Address correspondence to: Paul Fernyhough, R4046 - 351 Taché Avenue, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, R2H 2A6, Canada. Phone: 204.235.3692; E-mail: pfernyhough@sbrc.ca. Find articles by Smith, D. in: JCI | PubMed | Google Scholar 1Department of Pathology, UCSD, La Jolla, California, USA. 2Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada. 3Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA. 4Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Address correspondence to: Paul Fernyhough, R4046 - 351 Taché Avenue, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, R2H 2A6, Canada. Phone: 204.235.3692; E-mail: pfernyhough@sbrc.ca. Find articles by Frizzi, K. in: JCI | PubMed | Google Scholar 1Department of Pathology, UCSD, La Jolla, California, USA. 2Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada. 3Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA. 4Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Address correspondence to: Paul Fernyhough, R4046 - 351 Taché Avenue, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, R2H 2A6, Canada. Phone:

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Severe obesity may be caused by this genetic mutation

Gastric band Surgery In France Severe obesity may be caused by this genetic mutation Sign in Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences. Sign in Register for a free account For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more......>click Here< Read more... Read more...

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