GASTRIC BAND SURGERY & GASTRIC BANDING BARIATRIC LAP BAND OR TUMMY TUCK

Early-life exposures affect infant health

Research Update Jan. 9, 2017 Three recent studies have shown how dietary and other environmental exposures, including those that shape the internal environment created by gut microbes, are critically important during the first few years of life, with implications for a lifetime of good health. These exposures include not only the diet of the mother and child, but also other experiences that have a large impact on the bacterial populations of a child's gut, such as antibiotic treatment and delivery by vaginal or cesarean modes. More and more, the gut microbial community is being appreciated for its effects on human health, and the first 3 years of life is an important period for maturation of this gut microbial community. For example, by training the developing immune system, gut microbes are thought to play a possible role in guarding against autoimmune diseases such as type 1 diabetes and inflammatory bowel disease, as well as other immune-related diseases, including asthma and allergies. Early disturbances in the gut microbial community from such factors as antibiotics or cesarean delivery have also been linked to an increased risk for metabolic disorders, such as obesity. Studies by three research groups have delved into how great an impact these early exposures can have on infants, potentially affecting their future health. As part of the Healthy Start Study, researchers studied over 1,000 pairs of mothers and infants from multiple ethnic backgrounds to see how different types of foods eaten during pregnancy might affect infant body fat. The mothers were recruited during pregnancy. The researchers collected blood samples and information from the mothers on such subjects as physical activity and diet. Throughout pregnancy, participating mothers also completed several 24-hour dietary recalls online to provide a more complete picture of their diets. After delivery, information was collected in the hospital on the mothers and babies, including measurements of the infants' length, weight, and skin-fold thickness. The researchers also estimated the infants' body composition, including fat mass and fat-free mass. The mothers' diet quality was measured using a scoring system based on the 2010 Dietary Guidelines for Americans. The researchers found that consuming a lower-quality diet (e.g., more fat and sodium, and fewer fruits and vegetables) during pregnancy was associated with a higher percent of fat mass in the newborns, regardless of how much the women had weighed before pregnancy. The researchers plan to continue studying these infants to figure out what effect a larger fat mass at birth has on the risk of developing obesity in childhood and later in life. This study highlights a potential way to improve the health of newborns-eating more healthfully during pregnancy. Another research group followed the gut microbial development of 43 U.S. children during their first 2 years using genetic techniques to characterize the evolving community of

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