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Do liver cleanses work? Evidence and risks

Gastric band Surgery In France Do liver cleanses work? Evidence and risks Liver cleanses promise to rid the body of toxins and impurities, but they are controversial because there is little science to support their use.Products that claim to detox the liver might even be dangerous, and the United States Food and Drug Administration (FDA) do not regulate them. In this article, we look at how liver cleanses claim to work and what evidence exists to support them. What is a liver cleanse? A liver cleanse may involve may involve choosing or avoiding specific foods, or going on a juice fast. The liver is the body's natural detoxifier, as it cleanses the body of toxins and produces bile to support healthy digestion. A healthy liver can detoxify almost everything that a person encounters. The liver is on the right side of the body, just under the rib cage, When the liver is diseased, the body cannot filter out toxic substances as efficiently. This can cause a wide range of symptoms, including: A variety of natural health practitioners, supplement companies, and medical websites argue that the liver accumulates toxins during the filtering process. They insist that over time, these toxins can cause a range of nonspecific symptoms and may even cause serious diseases or increase the risk of cancer. There is little evidence to support this. Over time, however, exposure to chemicals can damage the liver. For example, drinking alcohol is a well-known way to ruin liver function over time. In most cases, a liver detox involves one or more of the following: taking supplements designed to flush toxins out of the liver eating a liver-friendly diet avoiding certain foods going on a juice fast cleansing the colon and gut through the use of enemas While liver failure is a serious health problem, there is no evidence that dangerous toxins accumulate in otherwise healthy livers without specific exposure to large amounts of these chemicals. Mainstream medical practitioners argue that the liver does not need detoxing and that doing so might even be dangerous. Should you try a liver cleanse? A healthy liver is crucial for maintaining a person's overall health, but expensive cleanses or diets are just not necessary. In some cases, they may even be dangerous. A healthy lifestyle, balanced diet, and regular consultations with a doctor are far more valuable to the health of the liver than any fad diet or cleanse. For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more......>click Here< Read more... Read more...

Intensive blood glucose management for those with type 1 diabetes preserves heart health for decades

​​A long-term NIDDK study reports that keeping blood glucose (sugar) as close to normal as possible for an average of 6.5 years early in the course of type 1 diabetes reduces cardiovascular (heart) disease for up to 30 years. The landmark Diabetes Control and Complications Trial (DCCT) began in 1983. The DCCT randomly assigned half its participants to an intensive blood glucose management regimen designed to keep blood glucose levels as close to normal as safely possible, and half to the less-intensive conventional treatment at the time. When DCCT ended in 1993, it was clear that intensive management had significantly reduced eye, nerve, and kidney complications, but at that time the participants were too young to determine their rates of cardiovascular disease. All DCCT participants were taught the intensive management regimen and invited to join the Epidemiology of Diabetes Interventions and Complications (EDIC) study. EDIC continued to monitor DCCT/EDIC participants' health, and overall blood glucose management has since been similar in both DCCT treatment groups. To study the long-term effects of the different treatments tested in the DCCT, researchers examined differences in cardiovascular problems, which can take many years to develop, between the former intensive and conventional treatment groups. After an impressive average 30-year follow-up, DCCT/EDIC researchers found that those who practiced intensive blood glucose management during the DCCT still had significantly reduced cardiovascular disease compared to those who did not, despite having similar blood glucose management for 20 years after the DCCT ended. Compared to the former conventional treatment group, the former intensive management group had a 30 percent reduced incidence of cardiovascular disease and 32 percent fewer major cardiovascular events (such as non-fatal heart attack, stroke, or death from cardiovascular disease), after 30 years of follow-up. These results were similar for both men and women who participated in the studies. However, the beneficial effects of intensively managing blood glucose during the DCCT appeared to be wearing off over time. Previously, after 20 years of follow-up, DCCT/EDIC researchers reported that the former intensive treatment group had a 42 percent reduced risk of cardiovascular disease compared to the former conventional treatment group. After 30 years of follow-up, that number had fallen to 30 percent. Even with this reduction in protection, these new data show that a finite period of near-normal blood glucose management early in the course of type 1 diabetes can have substantial beneficial effects on cardiovascular health for up to 30 years. Overall, this finding adds to DCCT/EDIC's decades of evidence demonstrating how people with type 1 diabetes can dramatically reduce their risk for complications later in life by practicing early, intensive blood glucose management. Read more......>click Here< Read more... Read more...

Siderophore Vaccine Conjugates Protect Against Uropathogenic Escherichia Coli Urinary Tract Infection.

Laura A. Mikea, Sara N. Smitha, Christopher A. Sumnera, Kathryn A. Eatona, and Harry L. T. Mobleya,1 aDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 Edited by Ralph R. Isberg, Howard Hughes Medical Institute/Tufts University School of Medicine, Boston, MA, and approved October 19, 2016 (received for review April 20, 2016) Significance Urinary tract infections (UTIs) are primarily caused by uropathogenic Escherichia coli (UPEC), and 1 in 40 women experience chronic UTIs during their lifetime. The antibiotic courses required to treat infections promote antibiotic resistance, and current vaccine options offer limited protection. We have pioneered a strategy using small iron-chelating compounds called siderophores as vaccine antigens. These siderophores are not produced by commensal bacteria and are required for UTI. The siderophore vaccines reported here are easy to formulate and reduce bacterial burdens in a murine model of UTI. This report highlights the untapped resource of bacteria-specific small molecules as potential vaccine antigens and provides a proof of principle for incorporating these compounds into multicomponent vaccines for the prevention of bacterial infections. Abstract Uropathogenic Escherichia coli (UPEC) is the primary cause of uncomplicated urinary tract infections (UTIs). Whereas most infections are isolated cases, 1 in 40 women experience recurrent UTIs. The rise in antibiotic resistance has complicated the management of chronic UTIs and necessitates new preventative strategies. Currently, no UTI vaccines are approved for use in the United States, and the development of a highly effective vaccine remains elusive. Here, we have pursued a strategy for eliciting protective immunity by vaccinating with small molecules required for pathogenesis, rather than proteins or peptides. Small iron-chelating molecules called siderophores were selected as antigens to vaccinate against UTI for this vaccine strategy. These pathogen-associated stealth siderophores evade host immune defenses and enhance bacterial virulence. Previous animal studies revealed that vaccination with siderophore receptor proteins protects against UTI. The poor solubility of these integral outer-membrane proteins in aqueous solutions limits their practical utility. Because their cognate siderophores are water soluble, we hypothesized that these bacterial-derived small molecules are prime vaccine candidates. To test this hypothesis, we immunized mice with siderophores conjugated to an immunogenic carrier protein. The siderophore-protein conjugates elicited an adaptive immune response that targeted bacterial stealth siderophores and protected against UTI. Our study has identified additional antigens suitable for a multicomponent UTI vaccine and highlights the potential use of bacterial-derived small molecules as antigens in vaccine therapies. Both the physical and financial burdens of urinary tract infections

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Knee osteoarthritis: What's the best weight loss plan?

Gastric band Surgery In France Knee osteoarthritis: What's the best weight loss plan? Sign in Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences. Sign in Register for a free account For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more......>click Here< Read more... Read more...

Effects of a Gut Pathobiont in a Gnotobiotic Mouse Model of Childhood Undernutrition.

Uncultured fecal gut microbiota from an underweight donor confers weight loss on gnotobiotic mice We used anthropometric data collected from members of a birth cohort study (14) of 100 children living in Mirpur thana in Dhaka, Bangladesh, to define whether they were healthy or undernourished (table S1). Those with height-for-age z scores (HAZ) greater than or equal to −2 were classified as "healthy," whereas those with scores less than or equal to −3 were deemed severely stunted. At 18 months, 30 and 25 children satisfied these criteria for healthy and severely stunted, respectively, whereas at 24 months, 27 and 20 children received these designations; the remaining children were classified as moderately stunted (HAZ between −2 and −3). A PCR-based screen for ETBF targeting all three fragilysin gene subtypes (14) was performed using DNA isolated from fecal samples that had been collected from these children at 18 and 24 months of age. The results revealed that ETBF was variably present between individuals and within a given individual over time, with a total of 25 of 24-month-old children having a positive test (table S1). In this small cohort, ETBF carriage was not significantly correlated with indices of linear or ponderal growth . We combined anthropometric and PCR data to select fecal samples collected at 24 months from two children: (i) a healthy individual (child ID 7114 in table S1) with a HAZ score of −0.71, a WAZ score of −1.49, and a WHZ score of −1.62 who was ETBF-negative at the two time points tested, and (ii) a severely stunted and moderately underweight individual (child ID 7004) with a HAZ score of −3.02, a WAZ score of −2.51, and a WHZ score of −1.34 who was ETBF-positive at both time points. Of the 35 individuals with a positive ETBF test at either time point, only this stunted/underweight child was positive at both 18 and 24 months of age. Fecal samples obtained from members of this singleton birth cohort were screened for parasites using microscopic methods (5); neither of the two donors tested positive (see Materials and Methods for details). To define the effects of diet and these two childrens' gut microbiota on host biology, we generated three representative versions (embodiments) of the diets consumed by the population represented by the donors. To do so, we determined the relative daily caloric contributions of various selected ingredient types, based on a study by Arsenault and coworkers (16). Selection of specific food items as representative of each ingredient type was based on consumption incidence surveys tabulated by Islam et al. (17), and the results were incorporated into a database consisting of 54 food ingredients. We filtered this database to remove items consumed by

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Being overweight may be more harmful than you thought

Gastric band Surgery In France Being overweight may be more harmful than you thought Sign in Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences. Sign in Register for a free account For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more......>click Here< Read more... Read more...

Why we choose the donut over the apple

Compare Gastric band Surgery In France Everyone knows that an apple per day is a more healthful option than a donut and yet, given the choice, many people would still choose the donut. A new study has revealed that food choices could be down to the associations that we make with food-related stimuli. person holding an apple in one hand and a doughnut in the other Researchers explain why the urge to eat a donut is mightier than the urge to eat an apple - even though the apple is the more healthful option. Aukje Verhoeven, Sanne de Wit, and Poppy Watson, all psychologists at the University of Amsterdam in the Netherlands, conducted the research. Their findings were published in the journal Appetite. The consumption of unhealthful foods is on the rise around the world, which is contributing to the more than 1.9 billion adults who are overweight globally. Among children in the United States, more than 27 percent of calories each day come from snacks, including salted snacks, candy, desserts, and sweetened beverages. This could have hazardous consequences for their health. Learned cues affect food choices Government initiatives have focused on making people more aware of the adverse effects of eating unhealthfully. However, most people fail to adhere to the recommended food guidelines, and eating behaviors often remain unchanged. Though it is not clear why informational interventions do not work, evidence suggests that food-related stimuli in the environment may play a role in triggering unhealthful eating habits. "Health warnings often make people want to choose healthier food products, yet many still end up picking unhealthy food products," explains Verhoeven. "We suspected this might partly be due to the fact that people learn to associate specific cues in their environment with certain food choices." For example, seeing a large "M" sign in the environment has been linked to reward, such as eating a cheeseburger, which then prompts a craving and could trigger a trip to the restaurant. These learned associations between cues and outcomes have a significant effect on the foods that people choose to consume. "Unhealthy choices are therefore automatically activated by learned associations, making health warnings, which focus on conscious choices, ineffective," Verhoeven adds. For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more......>click Here< Read more... Read more...

Deficiency in Prohormone Convertase PC1 Impairs Prohormone Processing in Prader-Willi Syndrome.

Research ArticleEndocrinologyGenetics Free access | 10.1172/JCI88648 Lisa C. Burnett,1,2,3 Charles A. LeDuc,2,3,4 Carlos R. Sulsona,5 Daniel Paull,6 Richard Rausch,2,3 Sanaa Eddiry,7 Jayne F. Martin Carli,2,3,8 Michael V. Morabito,2,3 Alicja A. Skowronski,1,2,3 Gabriela Hubner,9 Matthew Zimmer,6 Liheng Wang,2,3 Robert Day,10 Brynn Levy,11 Ilene Fennoy,12 Beatrice Dubern,13 Christine Poitou,13 Karine Clement,13 Merlin G. Butler,14 Michael Rosenbaum,2,3 Jean Pierre Salles,7,15 Maithe Tauber,7,15,16 Daniel J. Driscoll,5,17 Dieter Egli,2,3,6 and Rudolph L. Leibel2,3,4 1Institute of Human Nutrition, 2Department of Pediatrics, Division of Molecular Genetics, and 3Naomi Berrie Diabetes Center, Columbia University, New York, New York, USA. 4New York Obesity Research Center, New York, New York, USA. 5Department of Pediatrics, Division of Genetics and Metabolism, University of Florida College of Medicine Gainesville, Florida, USA. 6The New York Stem Cell Foundation Research Institute, New York, New York, USA. 7Centre de Physiopathologie de Toulouse-Purpan, Université de Toulouse, CNRS UMR 5282, INSERM UMR 1043, Université Paul Sabatier, Toulouse, France. 8Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA. 9Packer Collegiate Institute, New York, New York, USA. 10Institut de pharmacologie de Sherbrooke, Department of Surgery, Division of Urology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada. 11Department of Pathology and Cell Biology, Columbia University, New York, New York, USA. 12Department of Pediatrics, Division of Pediatric Diabetes, Endocrinology and Metabolism, Columbia University, New York, New York, USA. 13Institute of Cardiometabolism and Nutrition, Assistance Publique Hôpitaux de Paris, Sorbonne University, University Pierre et Marie-Curie, INSERM UMRS 1166, Paris, France. 14Department of Psychiatry and Behavioral Sciences, Division of Research and Genetics, Kansas University Medical Center, Kansas City, Kansas, USA. 15Unité d'Endocrinologie, Hôpital des Enfants, and 16Centre de Référence du Syndrome de Prader-Willi, CHU Toulouse, Toulouse, France. 17Center for Epigenetics, University of Florida College of Medicine, Gainesville, Florida, USA. Address correspondence to: Lisa C. Burnett or Rudolph L. Leibel, 1150 St. Nicholas Avenue Russ Berrie Pavilion Room 620 New York, NY 10033; Phone: 212 851 5315; E-mail: lmc2200@cumc.columbia.edu (L.C. Burnett); rl2332@cumc.columbia.edu (R.L. Leibel). Find articles by Burnett, L. in: JCI | PubMed | Google Scholar 1Institute of Human Nutrition, 2Department of Pediatrics, Division of Molecular Genetics, and 3Naomi Berrie Diabetes Center, Columbia University, New York, New York, USA. 4New York Obesity Research Center, New York, New York, USA. 5Department of Pediatrics, Division of Genetics and Metabolism, University of Florida College of Medicine Gainesville, Florida, USA. 6The New York Stem Cell

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Heart failure risk could be reversed with exercise program

Gastric band Surgery In France Heart failure risk could be reversed with exercise program Sign in Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences. Sign in Register for a free account For FREE No Obligation Information about the cost of Gastric Band Surgery in France Click here Or Click the Image Below to visit our Special offer Page to see if you Qualify for any Discounts Read more......>click Here< Read more... Read more...

Early-life exposures affect infant health

Research Update Jan. 9, 2017 Three recent studies have shown how dietary and other environmental exposures, including those that shape the internal environment created by gut microbes, are critically important during the first few years of life, with implications for a lifetime of good health. These exposures include not only the diet of the mother and child, but also other experiences that have a large impact on the bacterial populations of a child's gut, such as antibiotic treatment and delivery by vaginal or cesarean modes. More and more, the gut microbial community is being appreciated for its effects on human health, and the first 3 years of life is an important period for maturation of this gut microbial community. For example, by training the developing immune system, gut microbes are thought to play a possible role in guarding against autoimmune diseases such as type 1 diabetes and inflammatory bowel disease, as well as other immune-related diseases, including asthma and allergies. Early disturbances in the gut microbial community from such factors as antibiotics or cesarean delivery have also been linked to an increased risk for metabolic disorders, such as obesity. Studies by three research groups have delved into how great an impact these early exposures can have on infants, potentially affecting their future health. As part of the Healthy Start Study, researchers studied over 1,000 pairs of mothers and infants from multiple ethnic backgrounds to see how different types of foods eaten during pregnancy might affect infant body fat. The mothers were recruited during pregnancy. The researchers collected blood samples and information from the mothers on such subjects as physical activity and diet. Throughout pregnancy, participating mothers also completed several 24-hour dietary recalls online to provide a more complete picture of their diets. After delivery, information was collected in the hospital on the mothers and babies, including measurements of the infants' length, weight, and skin-fold thickness. The researchers also estimated the infants' body composition, including fat mass and fat-free mass. The mothers' diet quality was measured using a scoring system based on the 2010 Dietary Guidelines for Americans. The researchers found that consuming a lower-quality diet (e.g., more fat and sodium, and fewer fruits and vegetables) during pregnancy was associated with a higher percent of fat mass in the newborns, regardless of how much the women had weighed before pregnancy. The researchers plan to continue studying these infants to figure out what effect a larger fat mass at birth has on the risk of developing obesity in childhood and later in life. This study highlights a potential way to improve the health of newborns-eating more healthfully during pregnancy. Another research group followed the gut microbial development of 43 U.S. children during their first 2 years using genetic techniques to characterize the evolving community of

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